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Tuesday, 17 August, 2010

Highly concentrated right into the target

Cancer cells are hard to stop. They proliferate without regulation and thereby affect the healthy tissue. One possible way to fight their growth is to infiltrate anticancer agents right into the cells. In close collaboration three groups of the Cluster of Excellence “Nanosystems Initiative Munich (NIM)” developed a method using nanoparticles to smuggle concentrated Colchicine into the cells. Colchicine blocks the cell division and therefore stops the proliferation of cancer cells. The scientists of the Ludwig-Maximilians-Universität München used tiny silicate particles with an average of about 50 nanometers. The porous silicate easily absorbs the Colchicine and the particles are small enough to penetrate the cell membrane. To hinder the loss of agent on their way through the body the scientists developed a kind of protective layer. In only one production step they were able to coat the nanoparticles with a lipid bilayer. Thereby the Colchicine leaks only when the particles have passed the cell membrane. This principle is versatile usable, explains Prof. Bein:”Colchicine is only one example for many other agents which could be smuggled into the cells the same way”.

 Publication:

„Colchicine-loaded lipid bilayer-coated 50 nm mesoporous nanoparticles efficiently induce microtubule depolymerization upon cell uptake“,
Valentina Cauda, Hanna Engelke, Anna Sauer, Dephine Arcizet, Christoph Bräuchle, Joachim Rädler and Thomas Bein. Nano Lett. 2010, 10, 2484-2492

Contact:

Professor Thomas Bein

Department für Chemie der LMU

Tel.: 089 / 2180 – 77623

E-Mail: bein@lmu.de

Web: bein.cup.uni-muenchen.de

Complete press release (German)

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