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Monday, 26 October, 2009

NIM scientist gets highly endowed EU grant

The NIM scientist Jens Michalis receives a Starting Grant from the European Research Councils (ERC). Professor Michaelis, Department for Chemistry and Biochemistry at the Ludwig-Maximilians-Universität (LMU) München, gets 1.4 million Euro for five years. With the Starting Grant the ERC promotes seminal fundamental research by supporting excellent and creative scienstists.

Within his project „ATP-dependent nucleosome remodelling – Single molecule studies and super-resolution microscopy“ Jens Michaelis will investigate how the wrapping of the DNA in the cell nucleus alters. In higher cells the DNA strand is wrapped around so called histon proteins and formes the nucleosomes. Wrapped like this the DNA is very well protected. However from time to time it must be opened for access, for example for the read-out of the genetic information and its duplication. Thus the reconstruction of the nucleosome is an essential cellular process, which is not completely understood in detail up to now. Jens Michaelis now wants to visualize the dynamic and energy consuming process on a molecular level. Highly complex microscopic methods, partly devloped in Michaelis' labs, shall help to create a mechanistic model for the reconstruction process.

Contact:
Prof. Dr. Jens Michaelis
Department Chemie und Biochemie
Munich Center for Integrated Protein Science
Tel.: 089 / 2180 – 77561
www.cup.uni-muenchen.de/pc/michaelis
E-Mail: michaelis(at)lmu.de

 

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